- Apr 10 Auguste Franchomme, French cellist and composer, born in Lille, France (d. 1884)
- Apr 13 Antonio Meucci, Italian inventor (invented a telephone-like device), born in Florence, Grand Duchy of Tuscany (now Italy) (d. 1889)
- Apr 13 Henry Haywood Bell, U.S. Rear Admiral (Union Navy), born in Orange County, North Carolina (d. 1868)
- Apr 16 Caleb Blood Smith, American journalist and politician, 6th U.S. Secretary of the Interior, born in Boston, Massachusetts (d. 1864)
- Apr 26 Martha Finley, American children's book author (Elsie Dinsmore series), born in Chillicothe, Ohio (d. 1909)