- Apr 1 Giuditta Pasta, Italian soprano, dies at 67
- Apr 2 A. P. Hill, Confederate general, killed in action at 39
- Apr 2 Richard Cobden, English politician and manufacturer (founder of the Anti-Corn-Law League), dies at 60
- Apr 6 Colonel Reuben B Boston, US Confederate cavalry, killed in action during Battle of High Bridge in Farmville, Virginia at 30
- Apr 6 John Austin Wharton, American lawyer and Major General (Confederate Army), dies at 36
- Apr 8 John Park, Scottish composer, dies at 61
- Apr 9 Thomas Alfred Smyth, Irish/US Union general-major, dies at 32
- Apr 14 Ignaz Bösendorfer, Austrian musician, and piano maker, dies at 65
- Apr 14 Rafael Carrera, Guatemalan military commander and Dictator of Guatemala (1844–48, 1851–65), dies at 50
Abraham Lincoln (1809-1865)
Apr 15 16th US President (Republican: 1861-65), dies from gunshot wounds at 56
- Apr 16 Robert C. Tyler, US Confederate brigadier general, dies during the Battle of West Point, at 32
- Apr 22 Francis Washburn, US Union colonel/gen major, dies of injuries
- Apr 22 William McKean, American naval officer (Union Navy), dies at 64
- Apr 23 James Dearing, U.S. Brigadier General (Confederate Army), dies at 24
- Apr 26 Charles J Sax, Belgian musician, instrument maker, and father of Adolphe Sax - inventor of the saxophone, dies at 74
John Wilkes Booth (1838-1865)
Apr 26 American stage actor and assassin of US President Abraham Lincoln, shot and killed at 26 by Union soldier Boston Corbett
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide