- Apr 2 Paul van Vlissingen, Dutch ship owner, dies at 78
- Apr 3 Henriette Davidis, German cookery writer (Practical Cookbook), dies at 75
- Apr 9 Charles Goodyear, American politician (D-NY), dies at 71
- Apr 12 Joseph Dana Webster, American civil engineer and Brevet Major General (Union Army), dies at 64
- Apr 16 Augustin-Philippe Peellaert, Belgian military officer, painter, composer, and librettist, dies at 83
- Apr 19 Samuel Sebastian Wesley, English organist and composer, dies at 65
- Apr 27 George Aiken, American playwright and actor famous for writing the most popular stage adaptation of "Uncle Tom's Cabin", dies at 45
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide