- Apr 2 August Defresne, Dutch playwright and director (Anno Christi 969), dies at 67
- Apr 2 Wallingford Riegger, American cellist, composer (New Dance; Cooper Square), and educator, dies from head injuries in a dog walking accident at 75
- Apr 4 Simion Stoilow, Romanian mathematician (b. 1873)
- Apr 6 Jules Bordet, Belgian bacteriologist (syphillis, Nobel 1919), dies at 90
- Apr 7 Jesús Guridi, Spanish composer, dies at 74
- Apr 7 Marian Jordan, radio comedienne (Fibber McGee & Molly), dies at 62
- Apr 7 Yusef Greiss, Egyptian composer, dies at 61
- Apr 9 Zog I [Ahmed Zogu], King of Albania (1928-39), dies at 65
- Apr 10 Irene Warfield, American silent screen actress (Satan Sanderson), dies at about 65 [exact birthdate unconfirmed]
- Apr 11 Francis de Bourguignon, Belgian pianist (accompanist to Nellie Melba), and contemporary classical composer, dies at 70
- Apr 12 Nils-Eric Fougstedt, Finnish composer (Angoscia, Trittico sinfonico), dies at 50
- Apr 12 Philippine "Pine" Belder [Mary de Klerk], actress, dies at 93
- Apr 13 John A. Bennett, American convicted rapist, dies at 26
- Apr 21 James Melton, American pop (1920-30's) and operatic tenor (Metropolitan Opera, 1942-50), dies at 57
- Apr 24 (Joseph) Rosario Bourdon, French Canadian-American cellist, violinist, conductor, arranger and musical director (Victor Talking Machine Company, 1905-31; Symphonique de Montréal, 1935-44), dies at 76
- Apr 24 Lee Moran, American actor (Circus Clown), dies of heart ailment at 72 (b. 1888)
- Apr 25 Hans F Blunck, writer, dies
- Apr 27 Roy Del Ruth, American filmmaker (About Face, Folies Bergere), dies at 67
- Apr 29 (Gilbert) "Cisco" Houston, American folk singer, and guitarist, dies of stomach cancer at 42
- Apr 29 (Irving Milford) "Miff" Mole, American jazz trombonist, and composer (Red Nichols and His Five Pennies - "Slippin' Around"; Sophie Tucker), dies at 63
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide