- Sep 1 Jon Polito, American actor (Fire With Fire, Homicide: Life on the Street), dies from multiple myeloma at 65
- Sep 5 Hugh O'Brian, American actor (Wyatt Earp, Search), dies at 91
- Sep 9 James Stacy [Maurice William Elias], American actor (Lancer), dies at 79
- Sep 17 Charmian Carr, American actress (The Sound of Music), dies at 73
- Sep 20 Curtis Hanson, American film director and screenwriter (LA Confidential, 8 Mile), dies at 71
- Sep 24 Bill Nunn, American actor (Do the Right Thing), dies at 63
- Sep 28 Agnes Nixon, American television producer, director and writer (One Life to Live; All My Children), dies at 93
- Sep 28 Max Walker, Australian cricket fast bowler (34 Tests, 138 wickets) and broadcaster (Nine Network), dies at 68