- Apr 2 Thomas Howard Ruger, American lawyer and Brevet Major General (Union Army), born in Livingston County, New York (d. 1907)
- Apr 6 Johan Hendrik Kern, Dutch linguist (Sanskrit, Old Javan), born in Purworejo, Dutch East Indies (d. 1917)
- Apr 10 David McMurtrie Gregg, American diplomat and Brevet Major General (Union Army), born in Huntingdon, Pennsylvania (d. 1916)
- Apr 10 James Edward Rains, American lawyer and Brigadier General (Confederate Army), born in Nashville, Tennessee (d. 1862)
- Apr 17 Jean-Baptiste Accolay, Belgian composer, born in Brussels, Belgium (d. 1900)