- Apr 1 Isidore Legouix, French composer, born in Paris, France (d. 1916)
- Apr 1 Jim Fisk, American financier and "robber baron" of the Gilded Age known as Big Jim, born in Pownal, Vermont (d. 1872)
- Apr 21 William Rufus Terrill, American Brigadier General (Union Army), born in Covington City, Virginia (d. 1862)
- Apr 26 Artemus Ward [Charles Farrar Browne], American humorist (considered to be America's first stand-up comedian), born in Waterford, Maine (d. 1867)
- Apr 26 Horatio Richmond Palmer, American composer and choir director, born in Sherburne, New York (d. 1907)
- Apr 30 Lord Avebury [John Lubbock], British banker and politician, born in London (d. 1913)
Greatest Generation
Silent Generation
Baby Boomer
Generation X
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Generation Z