- Oct 3 Pleasant Adam Hackleman, Union brigadier general, dies in battle at 47
- Oct 4 William Duncan Smith, American Brigadier General (Confederate Army), dies at 36
- Oct 8 James Streshley Jackson, American attorney and Brigadier General (Union Army), dies in battle at 39
- Oct 8 William Rufus Terrill, American Union brigadier general, dies in battle at 28
- Oct 16 George B. Anderson, American Brigadier General (Confederate Army), dies at 31
- Oct 18 James Creighton, amateur American baseball player, dies of ruptured bladder from hitting home run on Oct 14th
- Oct 30 Ormsby McKnight Mitchel, American astronomer and Union Major General, dies at 53
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide