- Apr 3 James Clark Ross, British Royal Navy explorer (British Antarctic), dies at 61
- Apr 4 Harmen S Sytstra, Dutch poet/editor (Iduna), dies at 45
- Apr 6 Adley H. Gladden, American Brigadier General (Confederate Army), dies in battle at 51
- Apr 6 Albert Sidney Johnston, US Confederate general, dies in battle at 59
- Apr 7 Sydney Nelson, English song composer, dies at 62
- Apr 9 George W Johnson, US planter/Confederate (gov-Ky), dies at about 50
- Apr 10 William Harvey Lamb Wallace, American lawyer and Brigadier General, dies at 40
- Apr 19 Louis Powell Harvey, US governor of Wisconsin, drowns
- Apr 19 Simon Fraser, Canadian explorer and fur trader (explored the Fraser River), dies at 86
- Apr 25 Charles Ferguson Smith, US Union Gen-Maj, dies of infection at 55
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide