- Apr 11 Edward Canby, U.S. general (b. 1817)
- Apr 13 Carlo Coccia, Italian composer, dies at 90
- Apr 17 Semyon Stepanovich Gulak-Artemovsky, Ukrainian composer, baritone and playwright, dies at 60
- Apr 18 Justus von Liebig, German agricultural & biological chemist who is considered the founder of organic chemistry, dies at 69
- Apr 20 William Tite, English architect (The Royal Exchange), dies at 75
- Apr 25 Fyodor Petrovich Tolstoy, Russian painter (VP: Imperial Academy of Arts 1828-68), dies at 90
- Apr 27 William Charles Macready, British actor, manager, and diarist, dies at 80
- Apr 29 James Hope-Scott, English barrister and Tractarian (Anglo-Catholic movement), dies at 60
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide