- May 1 Danny Aiello III, American film and television stunt performer, stunt coordinator, and actor, dies of pancreatic cancer at 53
- May 1 Helen Wagner, American actress (Mister Peepers; As The World Turns), dies of natural causes at 91
Lynn Redgrave (1943-2010)
May 2 British-American actress (Gods and Monsters, Georgy Girl), dies of cancer at 67
- May 4 Ernie Harwell, American baseball broadcaster (Detroit Tigers, 1960-2002), dies at 92
- May 4 Zvonimir Levačić - Ševa, Croatian humorist and entertainer (b. 1943)
- May 7 Adele Mara [Adelaida Delgado], American actress, singer and dancer (Cool Million; Wheels), dies at 87
- May 9 Lena Horne, American actress and Grammy Award-winning singer (Cabin in the Sky; Stormy Weather; The Wiz), dies at 92
- May 23 Simon Monjack, English actor, producer, and writer (b. 1970)
- May 24 Ray Alan, English ventriloquist and television entertainer (Lord Charles), dies at 79
- May 24 Tapen Chatterjee, Bengali actor from India (b. 1937)
- May 25 Michael H. Jordan, businessman and former CEO PepsiCo and CBS Corporation (b. 1936)
- May 26 Art Linkletter, Canadian-American radio and television personality (People are Funny), dies at 97
- May 26 Jean Constantin, Romanian actor (b. 1928)
- May 27 Payut Ngaokrachang, Thai animator (The Adventure of Sudsakorn), dies at 81
- May 28 Eddie Barth [Edward Bartholetti], American actor and voiceover artist nicknamed "Mr. Gravel" for his raspy vocals (Shaft, Simon & Simon), dies at 78
- May 28 Gary Coleman, American actor (Diff'rent Strokes), dies at 42
Dennis Hopper (1936-2010)
May 29 American actor and director (True Grit, Blue Velvet, Easy Rider), dies at 74
- May 31 Brian Duffy, British photographer and film producer (b. 1933)
- May 31 Merata Mita, New Zealander filmmaker (Mauri, Patu!), dies at 67
- May 31 William A. Fraker, American cinematographer (b. 1923)
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