- Sep 3 Robert Schimmel, American stand-up comedian, dies after a car accident at 60
- Sep 4 Paul Conrad, American cartoonist (Pulitzer 1964, 71, 84), dies at 86
- Sep 7 Glenn Shadix, American actor (Beetlejuice), dies in a fall at 58
- Sep 11 Harold Gould, American character actor (The Sting, The Golden Girls, Rhoda, Big Bus), dies at 86
- Sep 11 Kevin McCarthy, American actor (Invasion of Body Snatchers, Death of a Salesman), dies of pneumonia at 96
- Sep 12 Claude Chabrol, French film director and screenwriter (b. 1930)
- Sep 21 Geoffrey Burgon, British jazz trumpeter, and film, television and concert composer (City Adventures), dies at 69
- Sep 25 Art Gilmore, American radio and television announcer (Highway Patrol), and actor, dies at 98
Gloria Stuart (1910-2010)
Sep 26 American actress (Titanic) and founder of the Screen Actors Guild, dies from respiratory failure at 100
- Sep 29 Greg Giraldo, American comedian (Comedy Central Roast), dies of an overdose at 44
Tony Curtis (1925-2010)
Sep 29 American actor (The Defiant Ones; Some Like It Hot; Spartacus), dies at 85