- Feb 14 Pandolfo Petrucci, Italian ruler of the Republic of Siena (1500-12) during the Renaissance, born in Siena, Italy (d. 1512)
Ferdinand II of Aragon (1452-1516)
Mar 10 King of Aragon (1479-1516), King of Naples (1504-16), born in Sada Palace, Sos, Aragon
Leonardo da Vinci (1452-1519)
Apr 15 Italian painter, sculptor, scientist and visionary, born in Vinci, Florence, Italy
- Jul 10 James III, King of Scots (1460-88), born in Stirling or St Andrews Castles (d. 1488)
Ludovico Sforza (1452-1508)
Jul 27 Italian duke of Milan (1494-1508) who commissioned The Last Supper, born in Vigevano (Modern day Lombardy), Italy
- Sep 21 Girolamo Savonarola, Italian Dominican friar who helped expel Medici from Florence, becoming the city's de facto ruler (1494-98), and preached against papal corruption, born in Ferrara, Duchy of Ferrara (now Italy) (d. 1498)
Richard III (1452-1485)
Oct 2 King of England (1483-85), born in Fotheringhay Castle, Northamptonshire, England
- Dec 10 Johannes Stöffler, German mathematician and astronomer, born in Blaubeuren, Germany (d. 1531)
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