- Feb 12 Lorenzo Campeggio Italian cardinal (legate for the Pope over English Henry VIII's first marriage), born in Milan (d. 1539)
- Mar 21 Angela Merici, Italian religious educator, founder of the Ursuline Order of nuns, and Roman Catholic saint, born near Desenzano del Garda, Republic of Venice (d. 1540)
- May 19 Isabella d'Este, Marquise of Mantua, born in Ferrara, Duchy of Ferrara (d. 1539)