- Mar 12 Giuliano de' Medici, Italian ruler of Florence (1513-16), born in Florence (d. 1516)
- Mar 26 Vasili III of Russia, Great Prince of Moscow (1505-33), son of Ivan III (d. 1533)
- May 5 Guru Amar Das, third Sikh Guru, born in Amritsar, Punjab, India (d. 1574)
- Jun 14 Giglio Gregorio Giraldi, Italian poet, born in Ferrara, Italy (d. 1552)
- Aug 14 Princess Catherine of York, 9th child and sixth daughter of King Edward IV by his wife Elizabeth Woodville, born in Eltham Palace, Greenwich, England (d. 1527)
- Nov 6 Johanna, the Insane, Queen of Castile (1504-20), born in Toledo, Spain (d. 1555)