Akechi Mitsuhide (1528-1582)
Mar 10 Japanese samurai who assassinated daimyō Oda Nobunaga, born in Tara Castle, Mino Province, Japan
- Jun 21 Maria of Austria, Holy Roman Empress (1564-76), born in Madrid, Spain (d. 1603)
- Jul 7 Anna of Austria, Duchess of Bavaria, daughter of Ferdinand I, born in Prague, Bohemia (d. 1590)
- Jul 8 Emanuel Philibert, Duke of Savoy (1553-1580, regained lands of Savoy), born in Chambéry, France (d. 1580)
- Aug 25 Luis de Requesens y Zúñiga, Spanish general and Governor of the Spanish Netherlands (1573-76), born in Barcelona, Spain (d. 1576)
- Oct 4 Francisco Guerrero, Spanish composer, born in Seville [exact day of birth unconfirmed] (d. 1599)
- Oct 25 Seerp Galama, Dutch nobleman, soldier and politician, born in Koudum, Netherlands (d. 1581)
- Nov 2 Peter Lotichius Secundus [Peter Lotz], Neo latin poet (Collected Works), born in Schlüchtern, Hesse, Germany (d. 1560)
- Nov 12 Qi Jiguang, Chinese general (Ming Dynasty general who led defense against Wokou pirates and the Great Wall), born in Luqiao (d. 1588)
- Nov 16 Jeanne d'Albret, Queen of Navarre (1555-72), mother of French King Henry IV, born in the royal palace of Saint-Germain-en-Laye, France (d. 1572)