- Apr 3 Anne Lister, English diarist 'the 1st modern lesbian', born in Halifax, England (d. 1840)
- Apr 9 George Peacock, English mathematician (algebraic theory), born in County Durham, England (d. 1858)
- Apr 12 Francis Preston Blair, American journalist and newspaper editor (Washington Globe), born in Abingdon, Virginia (d. 1876)
James Buchanan (1791-1868)
Apr 23 15th US President (1857-61), born in Cove Gap, Pennsylvania
- Apr 24 Nikolaj Bestuzhev, Russian Navy officer, writer and painter (Decembrist revolt), born in Saint Petersburg (d. 1855)
Samuel Morse (1791-1872)
Apr 27 American inventor (telegraph, Morse code) and painter, born in Charlestown, Massachusetts