- Mar 9 Leonardo Bruni, Italian humanist, statesman and historian (1st to divide history into Antiquity, Middle Ages, Modern), dies at about 74
- Apr 7 John Capreolus, French theologist (Libri IV), dies at about 50
- Apr 26 Robert Campin, first great master of Flemish and Early Netherlandish painting, dies at ~65
- May 20 Bernardino of Siena, Italian priest and Franciscan missionary, dies at 63
- May 27 John Beaufort, 1st Duke of Somerset, English military leader (b. 1404)
- Jun 23 Marcus [Manuel] Eugenicus, Byzantine bishop of Efeze/theologist, dies
- Nov 10 Wladyslaw III Warnenczyk, King of Poland and Hungary, dies in battle at 20
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide