- Feb 28 Isabella, Duchess of Lorraine (b. 1400)
- May 29 Constantine XI Palaeologus, last Byzantine Emperor (1449-53), dies in final defense of Constantinople against the Ottoman Turks at 49
- Jul 17 John Talbot, 1st Earl of Shrewsbury, English nobleman and military leader during the Hundred Years' War, killed in battle at 65 or 66 in the Battle of Castillon when his horse was fatally struck by an artillery shell and fell on top of him pinning him to the ground and allowing a French soldier to finish him off with a battleaxe