- Apr 18 Filippino Lippi, Italian renaissance painter, dies at ~52
- May 5 Anton of Burgundy, the Great Bastard, knight, dies at about 82
- May 31 Engelbert II, Count of Nassau-Dillenburg-Dietz and viceroy of Luxembourg, dies at 53
- Jul 2 Stephen III (Stefan the Great), ruler of Moldavia (1457-1504), dies
Isabella I of Castile (1451-1504)
Nov 26 Queen of Castile (1479-1504), patron of Christopher Columbus, who initiated the Spanish Inquisition with husband Ferdinand II of Aragon, dies at 53
- Dec 21 Bertold von Henneberg-Römhild, German archbishop and elector (b. 1442)
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide