- Feb 23 Gentile Bellini, Venetian painter (Sultan Mohammed II), dies at about 78 (burial date)
- Mar 12 Cesare Borgia, Duke of Valentinois, Italian aristocrat and illegitimate son of Pope Alexander VI, killed in a battle at 31
- Apr 2 Francis of Paola, Italian founder of the Order of the Minims (b. 1416)