- May 7 Franz von Sickingen, German knight/protect of poor, dies of wounds at 42
- May 23 Ashikaga Yoshitane, 10th Japanese shōgun of the Ashikaga shogunate, dies at 56
- Jul 1 Hendrik Voes, Flemish priest and church reformer, burned at the stake
- Jul 1 John of Esschen, Flemish priest and church reformer, burned at the stake
- Aug 13 Gerard David, Flemish painter
- Aug 29 Ulrich von Hutten, German knight, scholar and poet (led Imperial Knights against Roman Catholic Church), dies of syphilis at 35
- Sep 14 Adrian VI [Adriaan F Bieyens], only Dutch Pope (1522-23) and last non-Italian pope for 455 years, dies in office at 64
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning