- Jan 22 Andrea del Sarto, Italian painter, dies at 44
- Feb 16 Johannes Stöffler, German mathematician and astronomer, dies at 78
- Mar 6 Pedrarias Dávila, Spanish conquistador
- Mar 20 Sicke Freerks/Frericx [Cutter], Dutch anabaptist, beheaded
- Apr 5 Richard Roose, boiled to death for trying to poison an archbishop
- May 19 Jan Łaski, Polish statesman and diplomat (b. 1456)
- Jul 8 Tilman Riemenschneider, German sculptor, dies at 71
- Jul 17 Hosokawa Takakuni, Japanese military commander (b. 1484)
- Jul 23 Louis de Brézé, seigneur d'Anet, Marshal of Normandy and husband of Diane de Poitiers
- Sep 22 Louise Van Savoye, French regent of King Francis I, dies at 55
- Oct 11 Huldrych Zwingli, Swiss church reformer (Zwinglianen), dies
- Nov 24 Johannes Oecolampadius, German religious reformer (b. 1482)
- Dec 6 John Volkertsz Trimaker, Dutch anabaptist leader, beheaded
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning