- Mar 22 Johannes Magnus, last Catholic Archbishop of Sweden (b. 1488)
- Apr 30 Thomas Audley, 1st Baron Audley of Walden, Lord Chancellor of England
- May 29 Jacobus Latomus [Jasques Masson], Belgian inquisitor, dies at about 68
- Jun 14 Antoine, Duke of Lorraine and military leader (freed the Duchy of Lorraine from the Holy Roman Empire), dies at 55
- Jul 18 René van Chalon, viceroy of Holland, dies in battle at 25
- Jul 21 René of Chalon [Renatus of Nassau], prince of Orange, slain in battle
- Aug 28 Alardus Aemstelredamus, Dutch priest and humanist, dies at about 53
- Nov 15 King Jungjong of Joseon (b. 1506)
- Dec 9 Teofilo Folengo, Italian macaronic poet, dies at 53
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide