- Feb 13 Gian Paolo Lomazzo, Italian painter and poet (Trattato), dies at 61
- Feb 15 Jose the Acosta, Spanish missionary (Peru), dies at 59(?)
- Feb 17 Giordano Bruno, Italian friar and scholar, advocate of Copernican theory, executed at 51 or 52 (b. 1548) [1]
- Aug 2 Arent van Dorp, Dutch governor of East-Zealand, dies at about 70
- Aug 15 Johann Baptista Serranus, German singer and composer, dies at 60
- Sep 1 Tadeáš Hájek, Czech naturalist, physician and astronomer, dies at 74
- Sep 10 John Bruhesius [Bruhesen], bishop of Groningen, dies
- Oct 12 Luis Molina, Spanish Jesuit priest (De liberi arbitrii cum gratiae donis), dies at 65
- Oct 21 Toda Katsushige, Japanese warlord (b. 1557)
- Nov 3 Richard Hooker, English theologian (b. 1554)
- Nov 8 Natsuka Masaie, Japanese warlord (b. 1562)
- Nov 12 Andrew of Austria, Austrian nobleman (Margrave of Burgau), clergyman (Catholic cardinal and bishop), and Governor-General of the Habsburg Netherlands (1598-1599), dies at 42
- Nov 17 Kuki Yoshitaka, Japanese naval commander, commits seppuku (ritual suicide) after defeat at Battle of Sekigahara (b. 1542)
- Dec 12 John Craig, Scottish church reformer/James VI's court vicar, dies
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide