- Jan 26 Jean Hotman, Marquis de Villers-St-Paul, French diplomat (b. 1552)
- Feb 22 Santorio Sanctorius, Venetian physiologist and physician (invented thermometer), dies at 74
- Apr 18 Julius Caesar, English lawyer and judge, dies at 78
- Jun 13 George Gordon, 1st Marquess of Huntly, Scottish politician (b. 1562)
- Jul 20 John Oldham, English-born Puritan settler in Massachusetts, murdered by Indians at 44
- Oct 19 Marcin Kazanowski, Polish politician
- Dec 9 Fabian Birkowski, Polish writer (b. 1566)
- Dec 9 Giovanni B Aleotti, Italian writer/theater architect, dies at about 90
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide