Charles I (1600-1649)
Jan 30 King of England, Scotland, and Ireland (1625-49), beheaded for treason by Parliament at 48
- Mar 9 Henry Rich, 1st Earl of Holland, English soldier, executed at 58
- Mar 9 James Hamilton, 1st Duke of Hamilton, Scottish statesman, dies at 42
- Mar 16 Jean de Brébeuf, French Jesuit missionary and saint (mission with Huron people, published first French into Huron translation), tortured and killed by Iroquois in New France at 55
- Mar 17 Gabriel Lallemant, French Jesuit missionary, one of the Canadian Martyrs, tortured and killed by Iroquois (b. 1610)
- Mar 17 Gerardus Johannis Vossius [Gerrit Vos], Dutch regent, dies at 71
- Mar 19 Gerhard Johann Vossius, German classical scholar and theologian (b. 1577)
John Winthrop (1588-1649)
Mar 26 English Puritan lawyer and 1st governor of the Massachusetts Bay Colony, dies at 61
- May 12 Isaac Doreslaer, English lawyer/diplomat, murdered
- May 14 Friedrich Spanheim, Dutch theologian (b. 1600)
- Jun 3 Manuel de Faria e Sousa, Portuguese historian and poet, dies at 59
- Jun 20 Maria Tesselschade Visscher, Dutch writer and glass engraver (Muiderkring group), dies at 55
- Jun 30 Simon Vouet, French painter to the court of Louis XIII, dies at 59
- Jul 11 Margaret Coventry, 1st English earl of Shaftesbury, dies
- Jul 29 David Teniers I, Flemish painter (altaar stukken), dies
- Aug 2 Elisabeth Bas, Dutch businesswoman and wife of Admiral Swartenhondt, dies at about 78
- Aug 25 Richard Crashaw, English clergyman/poet, dies at about 36
- Sep 6 Famiano Strada, Italian jesuit (bello belgico decades duae), dies at 77
- Sep 6 Robert Dudley, English navigator and writer (Arcano del Mare), dies at 75
- Sep 15 John Floyd, English Jesuit preacher (b. 1572)
- Sep 28 Ottavio Vernizzi, Italian composer, dies at 79
- Oct 3 Giovanni Diodati, Swiss Protestant clergyman, dies at 73
- Oct 16 Isaac van Ostade, Dutch painter, buried at 28
- Oct 24 Ferdinand van Boisschot, Dutch diplomat, jurist and Chancellor of Brabant (1625-49), dies at 79
- Oct 28 Blanche Arundell, English noblewoman (led defense of Wardour Castle during English Civil War), dies at 65 or 66 [1]
- Nov 19 Caspar Schoppe, German scholar and controversialist, dies at 73
- Dec 4 Outgert Arisz Akersloot, Dutch silversmith, dies at about 73
- Dec 4 William Drummond of Hawthornden, Scottish poet, dies at 63
- Dec 7 Charles Garnier, French Jesuit missionary in New France, killed at 43
- Dec 8 Noël Chabanel, French Jesuit missionary (b. 1613)