- Jan 28 Johannes Hevelius, Polish astronomer who pioneered lunar topography (Prodromus Astronomiae - catalogue of over 1500 stars), dies on 76th birthday
- Feb 16 Charles Cotton, English poet and writer, dies at 56
- Mar 19 René-Robert Cavelier, sieur de La Salle, French explorer (Louisiana), killed by his men at 43
- Mar 22 Jean-Baptiste Lully, Italian-born French composer (Miserere Suites de Symphonies et Trios), dies at 54
- Mar 28 Constantijn Huygens, Dutch diplomat and poet, dies at 90
- Apr 12 Ambrose Dixon, Virginia Colony pioneer
- Apr 16 George Villiers, 2nd duke of Buckingham, English statesman and poet, dies at 59
- Jun 12 Jurriaen van Streeck, Dutch still life painter, buried
- Jul 19 Laura Martinozzi, Duchess of Modena (b. 1637)
- Sep 1 Henry More, English philosopher (b. 1614)
- Sep 28 Francis Turretin, Swiss theologian (b. 1623)
- Oct 13 Geminiano Montanari, Italian astronomer (b. 1633)
- Oct 21 Edmund Waller, English poet (Song: Go, lovely rose) and politician, dies at 81
- Oct 27 Renatus Rapinus [René Rapin], French Jesuit theologian and poet (Hortorum libri IV), dies at 65
- Nov 14 Eleanor "Nell" Gwyn, English mistress of King Charles II of England, dies from apoplexy at 37
- Dec 16 William Petty, English political economist and statistician (Treatise of Taxes and Contributions), dies at 64
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning