- Mar 22 Parliament of Breisach accepts French sovereignty over Elzas
- Jul 8 The first confirmed tornado in America kills a servant at Cambridge, Massachusetts
- Aug 10 Tewa medicine man, Popé, leads the Pueblo Rebellion against Spanish colonizers in the New Mexican Province, killing 400 and driving out another 2,000
- Aug 21 Pueblo Indians takes possession of Santa Fé in the New Mexican Province, from Spanish
- Sep 26 Tax revolt in Gorinchem due to tax on cereal
- Nov 14 Gottfried Kirch discovers the Great Comet of 1680 (Kirch's Comet/Newton's Comet)
- Dec 4 Hen in Rome lays a uniquely patterned egg, later believed to have predicted the arrival of the Kirch/Newton "Great Comet of 1680"
- Dec 15 Tax revolt on Terschelling due to tax on cereal
- Dec 31 De Italiaanse Opera (The Italian Opera) theater opens on the Leidsegracht in Amsterdam with "La Fatiche d'Ercole per Deianira" by PA Ziani
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