- Nov 10 The passenger ship Stephen Whitney is wrecked in thick fog off the southern coast of Ireland, killing 92 of the 110 on board. The disaster results in the construction the Fastnet Rock lighthouse.
- Nov 12 Sir James Young Simpson, a British physician, is the first to use chloroform as an anaesthetic
- Nov 21 Steamer "Phoenix" is lost on Lake Michigan, kills 200
- Nov 25 Friedrich von Flotow's comic romance opera "Martha" premiers at the Kärntnertortheater in Vienna
- Nov 26 Alfred de Mussets "Un Caprice" premieres in Paris
- Nov 28 Church of San Francisco dei Minori Conventuali in Bologna, Italy initiated with premier of Rossini's Tantum ergo
- Nov 29 Cayuse Indians kill missionaries Marcus & Narcissa Whitman, and 12 others at Waiilatpu Mission in Oregon Country (near present day Walla Walla, Washington)
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