- Apr 6 General railroad strike against "worgwetten" (anti-strike laws)
- Apr 6 In Holland, railroad and dock workers go out on strike, but the government passes anti-strike bills, calls out troops, and promptly ends the strike on the 13th April
- Apr 6 The Kishinev pogrom in Bessarabia begins, forcing tens of thousands of Jews to later seek refuge in Israel and the Western world.
- Apr 20 7th Boston Marathon won by Irishman John Lorden in 2:41:29.8
- Apr 22 American Power Boat Association forms
- Apr 22 NY Highlanders (Yankees) first MLB game; lose 3-1 before 11,950 vs Washington Senators at American League Park
- Apr 23 NY Highlanders (Yankees) win their first game; beat Washington Senators, 7-2 at American League Park
- Apr 27 1st Highlander (Yankee) shut-out, Philadelphia A's win 6-0
- Apr 27 Long Island's Jamaica Race Track opens
- Apr 29 Limestone slide at Turtle Mountain drops 30 million cubic metres (82 million tons) on to town of Frank, Alberta, Canada, kills 70-90 residents
- Apr 30 NY Highlanders (Yankees) inaugural home opener at Hilltop Park, Manhattan; beat Washington Senators, 6-2