- Mar 15 Anne de Montmorency, French Duke, soldier and statesman (Marshal and Constable of France, influential at court), born in Chantilly, France (d. 1567)
- Jun 5 Justus Jonas, German Protestant theologian and reformer, born in Nordhausen, Thuringia, Germany (d. 1555)
- Sep 28 Agnolo Firenzuola, Italian poet and litterateur, born in Florence (d. 1543)
Paracelsus (1493-1541)
Nov 11 Swiss physician and alchemist (Zinc, Laudanum), born in Einsiedeln, Switzerland
- Nov 12 Bartolomeo Bandinelli, Italian sculptor (d. 1560)