- Apr 9 John, Cardinal of Lorraine, French churchman, born in Bar-le-Duc, Lorraine (d. 1550)
- Nov 15 Eleanor of Austria, European noble - Queen of Portugal (1518-21), Queen of France (1530-47), Duchess of Touraine (1547–1558), born in Leuven, Habsburg Netherlands (now Belgium) (d. 1558)
- Dec 19 Andreas Osiander, German Protestant Reformation theologist, born in Gunzenhausen, Ansbach (d. 1552)