- Feb 10 Thomas Platter, Swiss humanist (d. 1582)
Juan Rodríguez Cabrillo (1499-1543)
Mar 13 Portuguese-Spanish conquistador who conquered Central America and later discovered California [birthdate is approximate], born in either Montalegre, Kingdom of Portugal or Palma del Río, Kingdom of Castile
- Mar 31 Pius IV [Gianangelo de' Medici], Italian lawyer and Pope (1559-65), born in Milan (d. 1565)
- Jun 24 Johannes Brenz, German theologist (Dutch Brentians), born in Weil der Stadt, Stuttgart (d. 1570)
- Sep 3 Diane de Poitiers, French mistress of Henry II of France, born in Saint-Vallier, Drôme, France (d. 1566)
- Oct 13 Claude of France, Duchess of Brittany and wife of Francis I of France, born in Romorantin-Lanthenay, France (d. 1524) [some sources cite October 14]
20-29
30-39
40-49
50-59
80-89
Over 90