Henry II (1519-1559)
Mar 31 King of France (1547-59), born in Château de Saint-Germain-en-Laye near Paris
Catherine de' Medici (1519-1589)
Apr 13 Italian born Queen consort to Henry II of France and later regent to her sons, born in Florence
- May 27 Girolamo Mei, Italian historian and editor of Greek texts, born in Florence (d. 1594)
- Jun 6 Andrea Cesalpino, Italian philosopher, physician and botanist, born in Arezzo, Italy (d. 1603)
- Jun 12 Cosimo I de Medici, Grand Duke of Tuscany and art patron of Florence, born in Florence (d. 1574)
- Jun 24 Theodore Beza, French Reformed Protestant theologian, born in Vezelay, Burgundy, Kingdom of France (d. 1605)
- Jul 20 Pope Innocent IX [Giovanni Antonio Facchinetti], 230th Catholic pope (1591), born in Bologna, Papal States (now Italy) (d. 1591)