Emperor Maximilian I (1459-1519)
Jan 12 Holy Roman Emperor (1508-19, established Hapsburg dynasty in Spain), dies at 59
- Jan 21 Vasco Núñez de Balboa, Spanish explorer executed on charges of treason at about 42 [birthdate undocumented, born c. 1475; exact death date uncertain, may have been as early as 15 January]
Leonardo da Vinci (1452-1519)
May 2 Italian painter, sculptor, scientist and visionary, dies at 67
- May 4 Lorenzo II de' Medici, Duke of Urbino, dies at 26
Lucrezia Borgia (1480-1519)
Jun 24 Italian noblewoman, daughter of Pope Alexander VI, dies at 39