- Jul 10 Humphrey Stafford, 1st Duke of Buckingham, English military leader (b. 1402)
- Aug 3 King James II of Scotland (b. 1430)
- Sep 20 Gilles Binchois, Franco-Flemish composer of early Renaissance music, dies at about 60
- Nov 13 Henry the Navigator, Portuguese Prince who sponsored Portuguese voyages of discovery, dies at 66
- Dec 14 Guarino da Verona, Italian Renaissance figure, dies at 86
- Dec 30 Richard Plantagenet, 3rd Duke of York, claimant to the English throne killed in Battle of Wakefield at 49 (b. 1411)
- Dec 31 Edmund, Earl of Rutland, brother of Kings Edward IV of England and Richard III of England, executed at 17
- Dec 31 Richard Neville, 5th Earl of Salisbury, English politician (b. 1400)
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide