Juan de la Cosa (c. 1450-60 - 1510)
Feb 28 Spanish cartographer, explorer and conquistador who designed the earliest European world map, shot with poison arrows and killed by indigenous people during an armed confrontation near modern day Turbaco, Colombia
- Mar 1 Francisco de Almeida, Portuguese soldier, explorer and 1st Viceroy of India dies at Table Bay, Africa at about 59
- Mar 10 Johann Geiler von Kaisersberg, Swiss-born preacher (b. 1445)
- May 17 Sandro Botticelli, Florentine Renaissance painter (Birth of Venus), dies at about 65
- May 25 Georges d'Amboise, French Roman Catholic cardinal, minister of state and viceroy in North Italy, dies at 49
- Aug 17 Edmund Dudley, English treasurer and author (Tree of Commonwealth), beheaded for treason on orders of King Henry VIII
- Aug 17 Richard Empson, English treasurer, beheaded on orders of Henry VIII at 59 or 60
- Oct 25 Il Giorgione [Giorgio del Castelfranco], Italian painter, dies at 32
- Dec 14 Duke Friedrich of Saxony, 36th Grand Master of the Teutonic Knights (1498-1510), dies at 37
- Dec 31 Bianca Maria Sforza, wife of Maximilian I, Holy Roman Emperor, dies at 38
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide