- Jan 2 William Smyth, English bishop & statesman, dies at ~54
- Jan 9 Anna of Brittany, Duchess of Brittany and the only woman to be Queen consort of France twice to Charles VIII (1491-98), and Louis XII (1499-1514), dies of a kidney stone attack at 36
- Mar 11 Donato Bramante, Italian architect (b. 1444)