- Jan 19 Barthout van Assendelft, 1st land advocate of Holland, dies
- Jan 23 Johannes Honter, Transylvanian Saxon humanist and theologian (b. 1498)
- Jan 28 Elia Levita, German-Yiddish writer (Habachur), dies at about 80
- Mar 20 Thomas Seymour of Sudely, English Lord Admiral, beheaded
- May 27 Lijsbeth Dirksdr, Fries antabaptist, drowns
- Jun 7 Eelke Fouckens, Frisian anabaptist, beheaded
- Nov 10 Paul III [Alessandro Farnese], Italian Pope (1534-49), dies at 81
- Dec 21 Marguerite of Navarre, Queen of Navarre, wife of Henry II of Navarre, dies at 57
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning