- Jan 23 Bernardo Pisano, Italian composer, dies at 57
- Mar 23 Itagaki Nobukata, retainer of Takeda Shingen
- Apr 1 Sigismund I the Old, King of Poland and Grand Duke of Lithuania (1506-48), dies at 81
- Jun 3 Juan de Zumárraga, 1st Spanish Catholic bishop of Mexico, author of "Doctrina breve" first complete book published in the Americas, dies at 79 or 80
- Jun 6 Juan de Castro, Portuguese explorer (b. 1500)
- Jun 14 Carpentras [Elzéar Genet], French composer, dies at about 78 [birthdate uncertain]
- Aug 6 Georg Rhau, German cantor, composer, and music publisher, dies at about 50 [exact birthdate uncertain c. 1488]
- Sep 5 Catharine Parr, Queen of England (1543-47), 6th wife of Henry VIII, dies at about 36
- Nov 16 Caspar Cruciger, German church reformer, dies at 44
- Dec 24 Maximilian of Egmond, Dutch count/stadholder of Frisia, dies
- Dec 27 Francesco Spiera, Italian Protestant jurist (b. 1502)
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide