Jane Grey (1537-1554)
Feb 12 Queen of England in 1553 for 9 days, beheaded for treason at 16
- Feb 12 Lord Guildford Dudley, Jane Grey's husband, beheaded at about 19 for treason
- Feb 21 Hieronymus Bock, German doctor (founder of modern botany), dies
- Feb 23 Henry Grey, Duke of Suffolk, Lady Jane Grey's father, executed
- Mar 3 Johann Friedrich, the Generous, Elector of Saxony (1532-47) and Head of the Protestant Confederation of Germany (the Schmalkaldic League), dies at 50
- Apr 11 Thomas Wyatt the younger, English rebel (b. 1521)
- Jun 19 Sixt Birck [Xystus Betulius], German writer and humanist (Judith), dies at 53
- Aug 25 Thomas Howard, 3rd Duke of Norfolk, English great admiral, dies
Francisco Vázquez de Coronado (1510-1554)
Sep 22 Spanish explorer and conquistador who led 1st European expedition to discover the Grand Canyon, dies of disease at about 44