- Jan 20 Miles Coverdale, English bishop and translator of the Great Bible (the first authorized English translation of the Bible), dies at about 80
- Feb 20 Mark van Vaernewijck, Flemish nobleman/politician, dies at 50
- Mar 13 Louis, Prince of Condé (1530-69), dies in Battle of Jarnac at 39
- May 10 Juan the Avila, Spanish minister/writer
- May 16 Dirk Willems, Anabaptist Martyr
- May 27 François de Coligny d'Andelot, French general (Jarnac) and Ruler of van Andelot, dies at 48
- Sep 5 Bernardo Tasso, Italian courtier and poet, dies at 75
- Sep 5 Pieter Bruegel, South Netherlands painter, dies at about 44
- Oct 9 Vladimir of Staritsa, Russian prince (b. 1533)
- Dec 23 St Philip II, Metropolitan of Moscow, martyred by Ivan the Terrible