- Jan 31 Claudio Aquaviva, Italian Jesuit priest (5th Superior General of the Society of Jesus), dies at 71
- Feb 4 Dom Justo Takayama, Japanese warlord (b. 1552)
- Feb 4 Giovanni Battista della Porta, Italian scholar, polymath and child prodogy (b. 1535)
- Mar 4 Hans von Aachen, German painter, dies
- Mar 6 Pieter Both, Dutch admiral/1st gov-gen (East Indies, 1609-14), drowns
- May 4 Adriaan van Roomen, Flemish mathematician (b. 1561)
- May 27 Margaret de Valois, 1st Queen of Henry IV of France (1672-99) daughter of Henry II, dies at 61
- Jun 3 Sanada Yukimura, Japanese samurai (b. 1567)
- Jun 23 Mashita Nagamori, Japanese warlord (b. 1545)
- Jul 26 Alonso Pérez de Guzmán, 7th Duke of Medina Sidonia, Spanish Armada commander, dies at 64
- Aug 15 Cornelis C. Vrancx, Flemish poet and writer (Comfort of Soles), dies
- Aug 15 Mír 'Imád al-Ḥasaní, Persian calligrapher (Master of the Nasta‘liq style - St. Petersburg Muraqqa), assassinated on Shah's authorization (b. 1554)
- Sep 1 Étienne Pasquier, French lawyer and man of letters, dies at 86
- Sep 27 Arbella Stuart, English great-great-granddaughter of King Henry VII and possible heir to the throne, dies imprisoned in the Tower of London at 39 or 40
- Nov 24 Sethus Calvisius, German composer, dies at 59
- Dec 2 Louis des Balbes de Berton de Crillon, French general
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning