- Apr 1 Cristofano Allori, Italian Mannerist painter (Judith), dies at 43
- Apr 15 John Carver, first governor of Plymouth Colony, dies at 45
- May 11 Johann Arndt, German Lutheran theologian and author of books on devotional Christianity, dies at 65
- May 15 Henrick de Keyser, Dutch architect and sculptor (master builder of Amsterdam, Zuiderkerk church), dies at 56
- Jun 8 Anne de Xainctonge, French saint and founder of the Society of the Sisters of Saint Ursula of the Blessed Virgin, dies at 53
- Jun 21 Kryštof Harant, Czech nobleman, soldier, writer, and composer, dies at about 57
- Jul 2 Thomas Harriot, English astronomer (1st person to draw map of the Moon with a telescope), dies at 61 or 62
- Jul 10 Karel Bonaventura Buquoy, French soldier (b. 1571)
- Jul 13 Albert VII, Archduke of Austria and cardinal-archbishop of Toledo, dies at 61
- Aug 3 Guillaume du Vair, French writer and thinker, dies at 65
- Aug 15 John Barclay, Scottish satirist writer and poet (Euphormio's Satyricon), dies at 39
- Sep 17 Roberto Bellarmino, Italian saint (Doctor of the Church), dies at 78
- Sep 24 Jan Karol Chodkiewicz, Polish military commander (b. 1560)
- Oct 8 Antoine de Montchrétien, French dramatist and economist, killed as part Huguenots rebellion
- Oct 16 Jan Pieterszoon Sweelinck, organist/composer, dies at about 59
- Nov 26 Radulph Agas, English surveyor (C. 1540)
- Nov 30 Francesco Rasi, Italian composer, singer, poet, and theorbo player, dies at 47
- Dec 13 Katarina Stenbock, Queen of Gustav I of Sweden (b. 1535)
- Dec 15 Charles d'Albert, duc of Luynes, French courtier, favourite of Louis XIII and Constable of France, dies at 43
- Dec 30 Saint Job of Maniava, Ukrainian Orthodox Saint (b. 1550)
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning