- Jan 17 Diego Alvarez de Paz, Span missionary/writer (Peru), dies at about 59
- Feb 19 Roemer Pieterszoon Visscher, Dutch poet, buried in Amsterdam at about 73
- Mar 9 Aegidius Albertinus, German writer (Lucifer's Kingdom), dies at 59
- Mar 17 Jan Sarkander, Polish-Czech Roman Catholic priest, martyr, and saint dies from injuries caused by torturing at 43
- Mar 25 Johannes Nucius, German composer and musicologist, dies at about 64 [exact birthday uncertain]
- May 6 Hayyim ben Joseph Vital, Palestinian-born Kabbalist (b. 1543)
- May 16 William Adams, English navigator, first ever Western Samurai who life was the basis for novel "Shōgun", dies in Japan at 55
- May 31 William Louis, Count of Nassau-Dillenburg and military commander (cousin to Maurice Prince of Orange), dies at 59
- Jun 16 Carlo Saraceni [Carlo Veniziano], Italian painter (Judith), dies
- Jun 29 John Aerts, Flemish sculptor
- Aug 18 Wanli, Emperor of Ming Dynasty, dies at 56
- Sep 26 Taichang Emperor [Zhu Changluo], 14th Emperor of the Ming dynasty of China, dies at 38
- Oct 7 Stanisław Żółkiewski, Polish military leader (b. 1547)
- Nov 7 Hetman Stanisław Żólkiewski polish commander in the Battle of Ţuţora (1620) (b. 1547)
- Nov 13 Louise de Coligny, French 4th wife of William of Orange, dies at Fontainebleau. at 65
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide