- Feb 12 George Heriot, Scottish goldsmith and philanthropist (b. 1563)
- Feb 13 Stephen Gosson, English satirist (b. 1554)
- Feb 17 Juan de Mariana, Spanish historian (b. 1536)
- Feb 21 Dirck van Baburen, Dutch painter (Sepulture), dies at about 28
- Jul 25 Steven van der Haghen, Dutch admiral, and governor of Ambon (1617-18), buried after having died from the plague at 61
- Sep 20 Isaac Le Maire, Amsterdam ship owner, dies at about 66
- Sep 23 Willem Pietersz Buytewech, Dutch painter and etcher, dies at about 32
- Nov 10 Henry Wriothesley, 3rd Earl of Southampton, English patron of the theater, dies at 51
- Nov 13 Thomas Erpenius [van Erpe], Dutch orientalist and Arabist (grammar), dies at 40
- Dec 5 Gaspard Bauhin, Swiss botanist (b. 1560)
- Dec 14 Charles Howard, 1st Earl of Nottingham, English statesman, dies at 73
- Dec 26 Simon Marius, astronomer, dies in Bavaria at 54
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide