- Feb 25 Marco da Gagliano, Italian opera composer, dies at 60
- Mar 1 Girolamo Frescobaldi, Italian keyboard virtuoso (organist at St. Peter's Basilica, 1608-28 and 1634-43), and late Renaissance/early Baroque dies at 59
- Apr 4 Simon Episcopius [Bisschop], Dutch theologist, dies at 60
- Apr 20 Christoph Demantius, German composer, dies at 75
- Jun 24 John Hampden, English politician, dies of injuries at about 48
- Jul 25 Robert Pierrepont, 1st Earl of Kingston-upon-Hull, English statesman (b. 1584)
- Aug 7 Hendrik Brouwer, Dutch explorer and Governor of the Dutch East Indies (1632-36), dies on an expedition to Chile at 62 [1]
- Aug 20 Anne Hutchinson, English Puritan preacher, killed in Native American uprising (b. 1591)
- Sep 15 Richard Boyle, Irish politician, 1st Earl of Cork, dies at 76
- Sep 16 Lucas Franchoys the Elder, Belgian painter, dies at 69
- Sep 20 Lucius Cary, 2nd Viscount Falkland, English politician and writer
- Oct 13 Sweder van Haersolte, mister of Swaluwenborch/diplomat, dies at 61
- Nov 3 John Bainbridge, English astronomer (b. 1582)
- Nov 3 Paul Guldin, Swiss astronomer and mathematician (Guldinus theorem), dies at 66
- Nov 17 Jean-Baptiste Budes, Comte de Guébriant, Marshal of France (b. 1602)
- Nov 29 Claudio Monteverdi, Italian composer and pioneer in development of opera (L'Orfeo,espro della Beata Vergine), dies at 76
- Nov 29 William Cartwright, English dramatist (b. 1611)
- Dec 8 John Pym, English statesman (b. 1583)
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning