- Jan 30 William Chillingworth, English scholar, theologian (The Religion of Protestants), and poet, dies at 41
- Mar 5 Louise Juliana of Nassau, countess consort of the Palatinate by marriage to Frederick IV, Elector Palatine of the Rhine, dies at 73
- Mar 24 Archduchess Cecilia Renata of Austria, Queen of Poland, dies at 32
Chongzhen (1611-1644)
Apr 25 16th and last Ming Emperor of China, commits suicide at 33
- Jun 15 John of Saint Thomas [João Poinsot], Portuguese Dominican friar, theologist, and philosopher, dies at 54
- Jul 2 William Gascoigne, English astronomer and mathematician (introduced telescopic sights), is killed in the Battle of Marston Moor at 24
- Jul 29 Urban VIII [Maffeo Barberini], Pope (1623-44), dies
- Aug 5 J. Henry Alting, German theologist (Statenvertaling), dies at 61
- Sep 4 John Wtenbogaert, Dutch theologist (Kerckelicke history), dies at 87
- Sep 7 Guido Bentivoglio, Italian statesman (b. 1579)
- Sep 8 Francis Quarles, English poet (Enchiridion), dies at 52
- Sep 8 John Coke, English politician (Secretary of State for Charles I, 1626-40), dies at 81
- Oct 6 Elisabeth of France, Queen consort of Philip IV of Spain (1621-44), dies at 41
- Nov 10 Luís Vélez de Guevara, Spanish writer (El diablo cojuelo), dies at 65
- Dec 30 Jan Baptist van Helmont, Flemish chemist (found boiling point temperature). dies at 65
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide