- Jan 5 Frederick of York, English duke/bishop/general, dies at 63
- Jan 30 Johann Philipp Christian Schulz, German composer, dies at 53
- Feb 2 Johann Nepomuk Kalcher, German organist, composer, and teacher of Carl Maria von Weber, dies at 62
- Feb 7 Franz Anton Dimmler, German composer, dies at 73
- Feb 17 Johann Heinrich Pestalozzi, Swiss educator (Leonard & Gertrude), dies at 81
- Feb 22 Charles Willson Peale, American painter remembered for portraits of leading American Revolution figures (George Washington), dies at 85
- Feb 26 David Moritz Michael, German composer who worked in America, dies at 75
- Mar 1 Christopher Gore, American lawyer and politician (8th Governor of Massachusetts), dies at 68
Alessandro Volta (1745-1827)
Mar 5 Italian physicist and inventor of the 1st battery, dies at 82
Ludwig van Beethoven (1770-1827)
Mar 26 German composer (5th Symphony; Ode to Joy), dies of liver disease at 56
- Mar 27 François Alexandre Frédéric, French social reformer (b. 1747)
- Apr 2 Ludwig Heinrich Bojanus, German physician and naturalist (b. 1776)
- Apr 3 Ernst Chladni, German physicist (Chladni's law - estimating the speed of sound), instrument inventor (euphon; clavicylinder), and musician, dies at 70
- Apr 13 Hugh Clapperton, Scottish explorer of Africa, dies at Sokoto, at 38
- Apr 22 Thomas Rowlandson, English artist and caricaturist, dies at 70
- Apr 23 Johanna Cornelia Wattier-Ziesenis, Dutch actress (Phaedra, Lady Macbeth), dies at 65
- Apr 24 Pierre-Joseph Candeille, French composer, dies at 82
- Apr 26 Bernardo Ottani, Italian composer, dies at 90
- May 5 Frederick Augustus I of Saxony (1806-27), dies at 76
- Jun 26 Christian A Vulpius, German writer (Ornaldo Ornaldini), dies
- Jun 26 Samuel Crompton, English inventor (mule-jenny spinning machine), dies at 73
- Jun 27 Johann Gottfried Eichhorn, German theologian (b. 1754)
- Jul 14 Augustin-Jean Fresnel, French physicist and optics pioneer (proved wave theory of light correct, invented catadioptric Fresnel lens), dies of tuberculosis at 39
- Aug 2 James Hewitt, American composer and conductor, dies at 57
George Canning (1770-1827)
Aug 8 British Prime Minister (Tory: 1827) and Foreign Secretary, dies in office at 57
William Blake (1757-1827)
Aug 12 English poet and artist (Songs of Innocence & Experience), dies at 69
- Aug 27 Ferdinand Trauttmansdorff, Austrian diplomat and statesman (ruled the Netherlands for Holy Roman Emperor), dies at 78
- Sep 18 Robert Pollok, Scottish poet (The Course of Time), dies of TB at 28
- Oct 10 Ugo Foscolo, Italian poet (Last Letters of Jacopo Ortis), dies at 49
- Nov 7 Bartolomeo Campagnoli, Italian violinist and composer, dies at 76
- Nov 18 Wilhelm Hauff, German writer, dies at 24
- Nov 20 Alexey Titov, Russian composer, dies at 58
- Nov 24 Herman Warner Muntinghe, Dutch lawyer, jurist (Cheif of Supreme Court of Dutch East Indies, 1908-19), and colonial director, dies at 54
- Nov 28 Dov Baer Schneersohn, Lubavitch leader/author (Imirei Binah), dies
- Dec 9 François Léonard Rouwyzer, composer, dies at 90
- Dec 26 Jan David Holland, composer, dies at 81